Blocked dihydropteridines as nitric oxide synthase activators
McInnes, Craig R. and Suckling, C.J. and Gibson, C.L. and Morthala, Raghavendar R. and Daff, Simon and Gazur, Ben (2010) Blocked dihydropteridines as nitric oxide synthase activators. Pteridines, 20. pp. 27-35. ISSN 0933-4807
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Abstract
It has been shown that 6-acetyl-7,7-dimethyl-5,6,7,8-tetrahydropteridin-4(3H)-one can act as a competent cofactor for the production of nitric oxide by neuronal nitric oxide synthase (nNOS). More information was sought on the structural features that could contribute to strong binding within the enzyme whilst maintaining a fast electron transfer rate. This study was concerned with expansion at the C2-position of the pteridine scaffold. The evidence suggests that expansion at the C2-position had a deleterious effect with respect to Km and as a consequence electron transfer rate. Unexpectedly, several lines of evidence suggested that a methyl substituent on nitrogen at C2 reduced the electron density in the pyrimidine and dihydropterin rings.
ORCID iDs
McInnes, Craig R., Suckling, C.J., Gibson, C.L. ORCID: https://orcid.org/0000-0003-4948-1266, Morthala, Raghavendar R., Daff, Simon and Gazur, Ben;-
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Item type: Article ID code: 27551 Dates: DateEvent2010PublishedSubjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry Depositing user: Ms Carol Khalaf Date deposited: 01 Oct 2010 14:50 Last modified: 06 Oct 2024 00:23 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/27551