The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease

Harnett, M.M. and Melendez, A.J. and Harnett, W. (2010) The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease. Clinical and Experimental Immunology, 159 (3). pp. 256-67. ISSN 0009-9104

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    Abstract

    The dramatic recent rise in the incidence of allergic or autoimmune inflammatory diseases in the West has been proposed to reflect the lack of appropriate priming of the immune response by infectious agents such as parasitic worms during childhood. Consistent with this, there is increasing evidence supporting an inverse relationship between worm infection and T helper type 1/17 (Th1/17)-based inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease, type 1 diabetes and multiple sclerosis. Perhaps more surprisingly, given that such worms often induce strong Th2-type immune responses, there also appears to be an inverse correlation between parasite load and atopy. These findings therefore suggest that the co-evolution of helminths with hosts, which has resulted in the ability of worms to modulate inflammatory responses to promote parasite survival, has also produced the benefit of protecting the host from pathological lesions arising from aggressive proinflammatory responses to infection or, indeed, aberrant inflammatory responses underlying autoimmune and allergic disorders. By focusing upon the properties of the filarial nematode-derived immunomodulatory molecule, ES-62, in this review we shall discuss the potential of exploiting the immunomodulatory products of parasitic worms to identify and develop novel therapeutics for inflammation.

    Author(s):Harnett, M.M., Melendez, A.J. and Harnett, W. ORCID logoORCID: https://orcid.org/0000-0001-9545-9401
    Item type:Article
    ID code:26173
    Keywords:allergy, autoimmune disease, ES-62, immunomodulation, inflammation, nematodes, Therapeutics. Pharmacology, Pharmacy and materia medica, Botanic, Thomsonian, and eclectic medicine, Immunology, Immunology and Allergy
    Subjects:Medicine > Therapeutics. Pharmacology
    Medicine > Pharmacy and materia medica
    Medicine > Botanic, Thomsonian, and eclectic medicine
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Strathprints Administrator
    Date deposited:27 May 2011 18:27
    Last modified:05 Jul 2019 03:14
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/26173
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