Modelling drug-eluting stents

McGinty, Sean and Mckee, Sean and Wadsworth, Roger and McCormick, Christopher (2010) Modelling drug-eluting stents. Mathematical Medicine and Biology, 28 (1). pp. 1-29. ISSN 0265-0746 (

Full text not available in this repository.Request a copy


In this study, we consider a family of mathematical models to describe the elution of drug from polymer-coated stents into the arterial wall. Our models include the polymer layer, the media, the adventitia, a possible topcoat polymer layer and atherosclerotic plaque. We investigate the relative importance of transmural convection, diffusion and drug-dependent parameters in drug delivery and deposition. Furthermore, we investigate how the release rate from the stent can be altered and examine the resulting effect on cellular drug concentrations.