Modelling drug-eluting stents

McGinty, Sean and Mckee, Sean and Wadsworth, Roger and McCormick, Christopher (2010) Modelling drug-eluting stents. Mathematical Medicine and Biology, 28 (1). pp. 1-29. ISSN 0265-0746 (https://doi.org/10.1093/imammb/dqq003)

Abstract

In this study, we consider a family of mathematical models to describe the elution of drug from polymer-coated stents into the arterial wall. Our models include the polymer layer, the media, the adventitia, a possible topcoat polymer layer and atherosclerotic plaque. We investigate the relative importance of transmural convection, diffusion and drug-dependent parameters in drug delivery and deposition. Furthermore, we investigate how the release rate from the stent can be altered and examine the resulting effect on cellular drug concentrations.

ORCID iDs

McCormick, Christopher ORCID: https://orcid.org/0000-0003-3157-1079

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• Item metadata

  Item type:	Article
  ID code:	26084
  Dates:	Date Event 22 April 2010 Published
  Subjects:	Science > Mathematics > Probabilities. Mathematical statistics Medicine > Therapeutics. Pharmacology
  Department:	Faculty of Science > Mathematics and Statistics Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Faculty of Engineering > Bioengineering
  Depositing user:	Strathprints Administrator
  Date deposited:	20 Sep 2010 10:28
  Last modified:	27 Mar 2025 21:43
  Related URLs:	Scopus publication http://imammb.oxfordjournals.org/content...
  URI:	https://strathprints.strath.ac.uk/id/eprint/26084