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Open Access research with a European policy impact...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the European Policies Research Centre (EPRC).

EPRC is a leading institute in Europe for comparative research on public policy, with a particular focus on regional development policies. Spanning 30 European countries, EPRC research programmes have a strong emphasis on applied research and knowledge exchange, including the provision of policy advice to EU institutions and national and sub-national government authorities throughout Europe.

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Serum profile of isosorbide mononitrate after vaginal administration in the third trimester

Bates, C.D. and Nicoll, A.E. and Mullen, A.B. and Mackenzie, F. and Thomson, A.J. and Norman, J.E. (2003) Serum profile of isosorbide mononitrate after vaginal administration in the third trimester. BJOG: An International Journal of Obstetrics and Gynaecology, 110 (1). pp. 64-67. ISSN 1470-0328

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Abstract

Vaginally administered nitric oxide donors such as isosorbide mononitrate have been used to ripen the uterine cervix in pregnancy. The pharmacokinetics of isosorbide mononitrate following vaginal administration are unknown. Serum levels of isosorbide mononitrate were determined at baseline and 60, 180 and 360 minutes after vaginal administration of 20 or 40 mg isosorbide mononitrate to pregnant women scheduled for induction of labour at term. Serum levels of isosorbide mononitrate continued to rise up to 360 minutes after isosorbide mononitrate insertion, with mean (SD) final levels of 337 (94) g/L following isosorbide mononitrate 40 mg and 144 (47) g/L following isosorbide mononitrate 20 mg, P < 0.01 .