Exact model reduction of combinatorial reaction networks

Conzelmann, Holger and Fey, Dirk and Gilles, Ernst D (2008) Exact model reduction of combinatorial reaction networks. BMC Systems Biology, 2. 78. ISSN 1752-0509 (https://doi.org/10.1186/1752-0509-2-78)

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Receptors and scaffold proteins usually possess a high number of distinct binding domains inducing the formation of large multiprotein signaling complexes. Due to combinatorial reasons the number of distinguishable species grows exponentially with the number of binding domains and can easily reach several millions. Even by including only a limited number of components and binding domains the resulting models are very large and hardly manageable. A novel model reduction technique allows the significant reduction and modularization of these models.