Spatial aspects of signalling by sphingosine 1-phosphate

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Pyne, S. and Lee, S.C. and Long, J. and Gillies, L. and Pyne, N.J. (2009) Spatial aspects of signalling by sphingosine 1-phosphate. Naunyn-Schmiedeberg's Archives of Pharmacology, 380 (4). p. 369. (https://doi.org/10.1007/s00210-009-0430-z)

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Abstract

Sphingosine kinase (SK) catalyses the phosphorylation of sphingosine to produce sphingosine 1-phosphate (S1P). S1P is a bioactive lipid that regulates cell proliferation, survival, migration etc. Extracellular S1P mediates its effects by binding to a family of five closely related G protein coupled receptors, S1P1-5. In addition, intracellular S1P may bind to undefined intracellular targets to elicit cellular responses. The focus of our recent work has

ORCID iDs

Pyne, S. ORCID logoORCID: https://orcid.org/0000-0002-6608-9584, Lee, S.C., Long, J., Gillies, L. and Pyne, N.J. ORCID logoORCID: https://orcid.org/0000-0002-5657-4578;
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