From selection to caged aptamers: identification of light-dependent ssdna aptamers targeting cytohesin

Mayer, G. and Lohberger, A. and Butzen, S. and Pofahl, M. and Blind, M. and Heckel, A. (2009) From selection to caged aptamers: identification of light-dependent ssdna aptamers targeting cytohesin. Bioorganic and Medicinal Chemistry Letters, 19 (23). pp. 6561-6564. (http://dx.doi.org/10.1016/j.bmcl.2009.10.032)

Abstract

Caged aptamers represent valuable tools for the spatiotemporal control of protein function by light. Here we describe a general route starting with the de novo selection process targeting cytohesin-1 and aiming at the synthesis of caged aptamers without the prior knowledge of detailed structural determinants of aptamer-target binding.

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• Item metadata

  Item type:	Article
  ID code:	18897
  Dates:	Date Event 1 December 2009 Published
  Subjects:	Medicine > Pharmacy and materia medica
  Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
  Depositing user:	Strathprints Administrator
  Date deposited:	20 May 2010 14:55
  Last modified:	11 Nov 2024 09:27
  URI:	https://strathprints.strath.ac.uk/id/eprint/18897