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Open Access research with a European policy impact...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the European Policies Research Centre (EPRC).

EPRC is a leading institute in Europe for comparative research on public policy, with a particular focus on regional development policies. Spanning 30 European countries, EPRC research programmes have a strong emphasis on applied research and knowledge exchange, including the provision of policy advice to EU institutions and national and sub-national government authorities throughout Europe.

Explore research outputs by the European Policies Research Centre...

Dynamic sensitivity and oscillation analysis of signal transduction networks

Jia, J.F. and Yue, H. (2010) Dynamic sensitivity and oscillation analysis of signal transduction networks. Journal of Sichuan University: Engineering Science Division, 42 (2). pp. 171-176. ISSN 1009-3087

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Abstract

In order to understand the complexity of cellular signaling pathways as nonlinear autonomous systems, their regulation mechanisms and robustness properties, the system dynamic characteristics of cellular networks were analyzed using perspectives of engineering and information sciences. Taking the NF-κB signaling transduction networks as an example , dynamic sensitivity analysis, nonlinear dynamic analysis were explored to study the parametric sensitivities and oscillation patterns with respect to the system output of cell signal transduction networks. The simulation results demonstrated that the output signal NF-κBn is relatively sensitive to eight key rate constants and the oscillation behavior of NF-κBn is obviously affected by the negative feedback function of IKK.