Imaging T-cell movement in the brain during experimental cerebral malaria

Ortolano, F. and Maffia, Pasquale and Dever, G. and Hutchison, S. and Benson, R. and Millington, O.R. and De Simoni, M.G. and Bushell, T. and Garside, P. and Carswell, H.V. and Brewer, J.M. (2009) Imaging T-cell movement in the brain during experimental cerebral malaria. Parasite Immunology, 31 (3). pp. 147-150. ISSN 0141-9838

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Abstract

T-cells are known to play a role in the pathology associated with experimental cerebral malaria, although it has not previously been possible to examine their behaviour in brain. Using multiphoton laser scanning microscopy, we have examined the migration and movement of these cells in brain tissue. We believe that this approach will help define host-parasite interactions and examine how intervening in these relationships affects the development of cerebral pathology.

Author(s):Ortolano, F., Maffia, Pasquale, Dever, G., Hutchison, S., Benson, R., Millington, O.R. ORCID logoORCID: https://orcid.org/0000-0002-3026-6550, De Simoni, M.G., Bushell, T. ORCID logoORCID: https://orcid.org/0000-0003-4145-9670, Garside, P., Carswell, H.V. ORCID logoORCID: https://orcid.org/0000-0002-0938-1212 and Brewer, J.M.
Item type:Article
ID code:13294
Keywords:brain, ECM, imaging, in vivo, microscopy, plasmodium, T lymphocytes, pharmacology, Therapeutics. Pharmacology, Pharmacy and materia medica, Microbiology, Immunology, Parasitology
Subjects:Medicine > Therapeutics. Pharmacology
Medicine > Pharmacy and materia medica
Science > Microbiology
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Ms Ann Barker-Myles
Date deposited:20 Oct 2009 14:05
Last modified:10 Jan 2020 22:49
URI:https://strathprints.strath.ac.uk/id/eprint/13294
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