Adrenaline reveals the torsadogenic effect of combined blockade of potassium channels in anaesthetized guinea pigs

Kane, K.A. and Michael, G. and Coker, S.J. (2008) Adrenaline reveals the torsadogenic effect of combined blockade of potassium channels in anaesthetized guinea pigs. British Journal of Pharmacology, 154 (7). pp. 1414-1426. ISSN 1476-5381 (http://dx.doi.org/10.1038/bjp.2008.169)

Abstract

Torsade de pointes (TdP) can be induced in several species by a reduction in cardiac repolarizing capacity. The aim of this study was to assess whether combined IKr and IKs blockade could induce TdP in anaesthetized guinea pigs and whether short-term variability (STV) or triangulation of action potentials could predict TdP.

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• Item metadata

  Item type:	Article
  ID code:	10370
  Dates:	Date Event August 2008 Published
  Subjects:	Medicine > Pharmacy and materia medica
  Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
  Depositing user:	Strathprints Administrator
  Date deposited:	22 Jun 2010 10:49
  Last modified:	11 Nov 2024 09:02
  URI:	https://strathprints.strath.ac.uk/id/eprint/10370