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Tuned methods for conjugate addition to a vinyl oxadiazole; synthesis of pharmaceutically important motifs

Burns, Alan R. and Kerr, Jennifer H. and Kerr, William J. and Passmore, Joanna and Paterson, Laura C. and Watson, Allan J. B. (2010) Tuned methods for conjugate addition to a vinyl oxadiazole; synthesis of pharmaceutically important motifs. Organic and Biomolecular Chemistry, 8 (12). pp. 2777-2783. ISSN 1477-0520

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Abstract

The addition of various nucleophiles to a vinyl 1,2,4-oxadiazole is described. Following optimisation, individual protocols tuned for the use of each specific class of reagent have been developed to allow the installation of nitrogen, sulfur, oxygen, and carbon nucleophiles, and leading to the preparation of a series of compounds containing the pharmaceutically important oxadiazole motif.