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The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by researchers from the Department of Computer & Information Sciences involved in mathematically structured programming, similarity and metric search, computer security, software systems, combinatronics and digital health.

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Tuned methods for conjugate addition to a vinyl oxadiazole; synthesis of pharmaceutically important motifs

Burns, Alan R. and Kerr, Jennifer H. and Kerr, William J. and Passmore, Joanna and Paterson, Laura C. and Watson, Allan J. B. (2010) Tuned methods for conjugate addition to a vinyl oxadiazole; synthesis of pharmaceutically important motifs. Organic and Biomolecular Chemistry, 8 (12). pp. 2777-2783. ISSN 1477-0520

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Abstract

The addition of various nucleophiles to a vinyl 1,2,4-oxadiazole is described. Following optimisation, individual protocols tuned for the use of each specific class of reagent have been developed to allow the installation of nitrogen, sulfur, oxygen, and carbon nucleophiles, and leading to the preparation of a series of compounds containing the pharmaceutically important oxadiazole motif.