The role of GPX1 (rs1050450) variants in ovarian cancer susceptibility within a Turkish population

Tools

Alsheikh, Baker and Attar, Rukset and Güleç Yilmaz, Seda and Yaser Barham, Sara and Bakırezer, Selvi Duman (2025) The role of GPX1 (rs1050450) variants in ovarian cancer susceptibility within a Turkish population. Cancer Control, 32. ISSN 1526-2359 (https://doi.org/10.1177/10732748251332441)

[thumbnail of Alsheikh-etal-CC-2025-The-role-of-GPX1-rs1050450-variants-in-ovarian-cancer-susceptibility]
Preview
 Text. Filename: Alsheikh-etal-CC-2025-The-role-of-GPX1-rs1050450-variants-in-ovarian-cancer-susceptibility.pdf
Final Published Version
License: Creative Commons Attribution-NonCommercial 4.0 logo
Download (870kB)| Preview

Abstract

Introduction: Ovarian cancer (OC) remains one of the most lethal gynecological malignancies, primarily due to challenges in early detection and the consequent poor prognosis. Genetic predisposition plays a critical role in OC development, with the Glutathione Peroxidase 1 (GPX1) gene receiving increasing attention. The GPX1 gene polymorphism rs1050450 has been implicated in various cancers, potentially through its impact on oxidative stress mechanisms. Objective: This study aimed to investigate the association between the GPX1 (rs1050450) polymorphism and the risk of developing OC in a Turkish population. Methods: A retrospective case-control study was conducted involving 90 women diagnosed with OC and 90 healthy controls. Genotyping of the GPX1 (rs1050450) polymorphism was performed using real-time PCR (RT-PCR). Statistical analyses were conducted using the SPSS software, with chi-square and t-tests applied where appropriate. Results: The CC genotype of the GPX1 (rs1050450) polymorphism was significantly associated with a reduced risk of OC (P = 0.002; OR = 0.304; 95% CI = 0.161-0.577), whereas the TT genotype was linked to an increased risk, demonstrating a threefold elevation in susceptibility (P = 0.036; OR = 3.308; 95% CI = 1.024-10.682). Additionally, the T allele was associated with an approximately threefold increased risk of developing OC (P = 0.0002). Conclusion: These findings suggest that the GPX1 (rs1050450) polymorphism may play a significant role in OC susceptibility, with the CC genotype offering potential protective effects and the TT genotype indicating increased risk. This genetic variant may serve as a useful marker for assessing OC risk; however, further studies involving larger and more diverse populations are needed to validate these results.

ORCID iDs

Alsheikh, Baker, Attar, Rukset, Güleç Yilmaz, Seda, Yaser Barham, Sara ORCID logoORCID: https://orcid.org/0009-0002-7351-4793 and Bakırezer, Selvi Duman;
CORE (COnnecting REpositories)