Relative strength variability measures for brain structural connectomes and their relationship with cognitive functioning

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Yeung, Hon Wah and Buchanan, Colin R. and Moodie, Joanna and Deary, Ian J. and Tucker-Drob, Elliot M. and Bastin, Mark E. and Whalley, Heather C. and Smith, Keith M. and Cox, Simon R. (2025) Relative strength variability measures for brain structural connectomes and their relationship with cognitive functioning. Other. bioRxiv, Cold Spring Harbor, NY. (https://doi.org/10.1101/2025.03.15.643458)

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Abstract

In this work, we propose a new class of graph measures for weighted connectivity information in the human brain based on node relative strengths: relative strength variability (RSV), measuring susceptibility to targeted attacks, and hierarchical RSV (hRSV), a first weighted statistical complexity measure for networks. Using six different network weights for structural connectomes from the UK Biobank, we conduct comprehensive analyses to explore relationships between the RSV and hRSV, and (i) other known network measures, (ii) general cognitive function ('g'). Both measures exhibit low correlations with other graph measures across all connectivity weightings indicating that they capture new information of the brain connectome. We found higher g was associated with lower RSV and lower hRSV. That is, higher g was associated with higher resistance to targeted attack and lower statistical complexity. Moreover, the proposed measures had consistently stronger associations with g than other widely used graph measures including clustering coefficient and global efficiency and were incrementally significant for predicting g above other measures for five of the six network weights. Overall, we present a new class of weighted network measures based on variations of relative node strengths which significantly improved prediction of general cognition from traditional weighted structural connectomes.

ORCID iDs

Yeung, Hon Wah, Buchanan, Colin R., Moodie, Joanna, Deary, Ian J., Tucker-Drob, Elliot M., Bastin, Mark E., Whalley, Heather C., Smith, Keith M. ORCID logoORCID: https://orcid.org/0000-0002-4615-9020 and Cox, Simon R.;
CORE (COnnecting REpositories)