Developmental overproduction of cortical superficial neurons impairs adult auditory cortical processing
Merkler, Mirna and Ip, Nancy y. and Sakata, Shuzo (2025) Developmental overproduction of cortical superficial neurons impairs adult auditory cortical processing. Scientific Reports. ISSN 2045-2322 (In Press)
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Abstract
While evolutionary cortical expansion is thought to underlie the evolution of human cognitive capabilities, excessive developmental expansion can lead to megalencephaly, often found in neurodevelopmental disorders. Still, little is known about how the overproduction of cortical neurons during development affects cortical processing and behavior in later life. Here we show that developmental overproduction of cortical superficial neurons impairs auditory processing in adult mice. We applied XAV939 to overproduce cortical superficial excitatory neurons during development. XAV939-treated adult mice exhibited auditory behavioral deficits and abnormal auditory cortical processing. Furthermore, we found fewer functional monosynaptic connections between cortical putative excitatory neurons. Altogether, our results suggest that abnormal auditory cortical processing contributes to the atypical auditory detectability in XAV939-treated mice. Although the expansion of cortical size is evolutionarily advantageous, an abnormal expansion during development can result in detrimental effects on cortical processing and perceptual behavior in adulthood.
ORCID iDs
Merkler, Mirna

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Item type: Article ID code: 92464 Dates: DateEvent25 March 2025Published25 March 2025Accepted14 November 2024SubmittedSubjects: Medicine > Internal medicine > Neuroscience. Biological psychiatry. Neuropsychiatry Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 26 Mar 2025 15:36 Last modified: 27 Mar 2025 09:28 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/92464