Investigation of polymorphisms in global genome repair genes in patients with ovarian cancer in the Turkish population

Barham, Sara Yaser and Omotade, Dorcas and Yılmaz, Seda and Akdeniz, Fatma Tuba and Goralı, Betül Çapar and Attar, Rukset and İsbir, Turgay (2024) Investigation of polymorphisms in global genome repair genes in patients with ovarian cancer in the Turkish population. Cancer Control, 31. ISSN 1526-2359 (https://doi.org/10.1177/10732748241270597)

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Abstract

Introduction: Ovarian cancer (OC) poses significant challenges due to its high mortality rate, particularly in advanced stages where symptoms may not be evident. DNA repair mechanisms, including nucleotide excision repair (NER), are crucial in maintaining genomic stability and preventing cancer. This study focuses on exploring the role of two NER-related genes, Xeroderma Pigmentosum Complementation Group C (XPC) and DNA Damage Binding Protein 2 (DDB2), in OC susceptibility. Objectives: This study aims to investigate the association between variations in two NER-related genes, XPC rs2228001 and DDB2 rs830083, among a cohort of Turkish individuals with OC and control subjects. Methods: Genotyping of XPC rs2228001 and DDB2 rs830083 was performed on 103 OC patients and 104 control subjects from the Turkish population using the Fast Real-Time 7500 PCR platform from Applied Biosystems. Results: Individuals with the homozygous AA genotype of XPC rs2228001 exhibited a reduced likelihood of developing OC (OR 0.511; 95% CI 0.261 - 1.003; P-value 0.049), whereas those with the CC variant faced an elevated risk (OR = 2.32, 95% CI = 1.75-3.08; P-value 0.035). The presence of the A allele was associated with decreased OC occurrence (P-value = 0.035). Similarly, for DDB2 rs830083, individuals with the homozygous CG genotype had a diminished risk of OC (P-value 0.036), compared to those with the GG polymorphism (OR 1.895; 95% CI 1.033 - 3.476; P-value 0.038). Furthermore, the presence of the C allele was associated with a 1.89-fold decrease in the likelihood of OC. Conclusion: These findings shed light on the genetic factors influencing OC susceptibility, emphasizing the importance of DNA repair systems in disease. Further research in larger and more diverse populations is warranted to validate these findings, facilitating precise risk assessment, and potentially guiding tailored treatment strategies for OC patients.

ORCID iDs

Barham, Sara Yaser ORCID logoORCID: https://orcid.org/0009-0002-7351-4793, Omotade, Dorcas, Yılmaz, Seda, Akdeniz, Fatma Tuba, Goralı, Betül Çapar, Attar, Rukset and İsbir, Turgay;
CORE (COnnecting REpositories)