Antimicrobial use among hospitalized neonates and children; findings and implications from a comprehensive point prevalence survey among general tertiary hospitals in Pakistan

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Mustafa, Zia Ul and Salman, Muhammad and Khan, Amer Hayat and Harun, Sabariah Noor and Meyer, Johanna C. and Godman, Brian (2024) Antimicrobial use among hospitalized neonates and children; findings and implications from a comprehensive point prevalence survey among general tertiary hospitals in Pakistan. Infection and Drug Resistance, 17. pp. 5411-5428. (https://doi.org/10.2147/IDR.S491454)

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Abstract

Purpose: Antimicrobial resistance is a global health crisis exacerbated by excessive and inappropriate use of antibiotics especially among low- and middle-income countries including Pakistan. The paediatric population is a key area in view of their vulnerability and excessive prescribing of antibiotics in Pakistan. Consequently, there is an urgent need to robustly assess antimicrobial use among hospitalized neonates and children in tertiary hospitals in Pakistan as they are generally the training centres for new physicians subsequently treating children. Patients and methods: A point prevalence survey (PPS) was conducted in the children’s wards of 11 tertiary care hospitals in Punjab Province, covering over 50% of the population of Pakistan. This builds on a previous PPS among tertiary care hospitals treating exclusively neonates and children. Results: 1,811 neonates and children were surveyed with 1,744 patients prescribed antibiotics, a prevalence of 96.3%. 2,747 antibiotics were prescribed to these 1,744 neonates and children, averaging 1.57 antibiotics per patient. 57.7% of the patients were prescribed one antibiotic and 27.2% two antibiotics, with 85.6% of antibiotics administered parenterally. 34.4% of the antibiotics were prescribed prophylactically, with 44.7% of these for surgical procedures. Among those prescribed an antibiotic for surgical procedures, 75.2% were prescribed for more than one day. Overall, 92.2% of antibiotics were prescribed empirically with 86.2% prescribed without mentioning the rationale for their choice in the notes with 77.6% having no stop date. Respiratory tract infections were the most common indication (43.4%). Staphylococcus species (36.0%) were the most common pathogen with limited CST performed. 75.2% of antibiotics were from the ‘Watch’ list and 24.4% were ‘Access’ antibiotics. Conclusion: A very high prevalence of antibiotic use among neonates and children in tertiary hospitals in Pakistan, including ‘Watch’ antibiotics, mirroring previous studies. Consequently, initiatives including antimicrobial stewardship programmes, are urgently needed to address current inappropriate prescribing.

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