The genus Serratia revisited by genomics

Williams, David J. and Grimont, Patrick A.D. and Cazares, Adrián and Grimont, Francine and Ageron, Elisabeth and Pettigrew, Kerry A. and Cazares, Daniel and Njamkepo, Elisabeth and Weill, François Xavier and Heinz, Eva and Holden, Matthew T.G. and Thomson, Nicholas R. and Coulthurst, Sarah J. (2022) The genus Serratia revisited by genomics. Nature Communications, 13 (1). 5195. ISSN 2041-1723 (https://doi.org/10.1038/s41467-022-32929-2)

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Abstract

The genus Serratia has been studied for over a century and includes clinically-important and diverse environmental members. Despite this, there is a paucity of genomic information across the genus and a robust whole genome-based phylogenetic framework is lacking. Here, we have assembled and analysed a representative set of 664 genomes from across the genus, including 215 historic isolates originally used in defining the genus. Phylogenomic analysis of the genus reveals a clearly-defined population structure which displays deep divisions and aligns with ecological niche, as well as striking congruence between historical biochemical phenotyping data and contemporary genomics data. We highlight the genomic, phenotypic and plasmid diversity of Serratia, and provide evidence of different patterns of gene flow across the genus. Our work provides a framework for understanding the emergence of clinical and other lineages of Serratia.

ORCID iDs

Williams, David J., Grimont, Patrick A.D., Cazares, Adrián, Grimont, Francine, Ageron, Elisabeth, Pettigrew, Kerry A., Cazares, Daniel, Njamkepo, Elisabeth, Weill, François Xavier, Heinz, Eva ORCID logoORCID: https://orcid.org/0000-0003-4413-3756, Holden, Matthew T.G., Thomson, Nicholas R. and Coulthurst, Sarah J.;
  • Item type:Article
    ID code:90646
    Dates:
    Date
    Event
    3 September 2022
    Published
    24 August 2022
    Accepted
    Subjects:Science > Microbiology
    Department:UNSPECIFIED
    Depositing user: Pure Administrator
    Date deposited:23 Sep 2024 12:37
    Last modified:18 Nov 2024 13:53
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/90646
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