Mathematical insight of methanol toxicity management using charcoal and folinic acid
Sardar, Sanju and Roy, Priti Kumar and Kushary, Subhankar and Greenhalgh, David; Roy, Priti Kumar and Bhattacharya, Arindam and Cao, Xianbing and Li, Xue-Zhi, eds. (2025) Mathematical insight of methanol toxicity management using charcoal and folinic acid. In: Mathematical Analysis and Applications in Biological Phenomena through Modelling - ICMAAM-2023. Springer Proceedings in Mathematics & Statistics . Springer, IND, pp. 239-249. ISBN 9789819791941 (https://doi.org/10.1007/978-981-97-9194-1_17)
![]() |
Text.
Filename: Sardar-et-al-Mathematical-insight-of-Methanol-Toxicity-Management-using-Charcoal-and-Folinic-Acid.pdf
Accepted Author Manuscript Restricted to Repository staff only until 2 February 2026. Download (474kB) | Request a copy |
Abstract
Methanol poisoning is a relatively uncommon yet highly perilous form of intoxication, leading to central nervous system depression, vision impairment, metabolic disruption, and even more deadly consequences if not quickly and effectively addressed. Keeping this in mind, this work primarily studies activated charcoal as first aid for methanolintoxicated persons. In this research article, we initially develop a mathematical model for methanol-enzyme interaction, along with the effects of folate therapy. We consider a unique form of the Dubinin-Astakhov (DA) equation that characterizes the adsorption of methanol on activated charcoal. The impulsive differential equation which we formulate, based on the DA equation, examines the efficacy of activated charcoal in treating methanol toxicity. We also verify all our analytical results using numerical simulations.
ORCID iDs
Sardar, Sanju, Roy, Priti Kumar, Kushary, Subhankar and Greenhalgh, David
-
-
Item type: Book Section ID code: 90040 Dates: DateEvent2 February 2025Published30 June 2024AcceptedSubjects: Science > Mathematics Department: Faculty of Science > Mathematics and Statistics Depositing user: Pure Administrator Date deposited: 25 Jul 2024 13:04 Last modified: 28 Mar 2025 17:02 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/90040