A monoclinic polymorph of chlorothiazide

Brydson, Rowan K. H. and Kennedy, Alan R. (2024) A monoclinic polymorph of chlorothiazide. Acta Crystallographica Section E: Structure Reports, 80 (Pt 7). pp. 806-810. ISSN 1600-5368 (https://doi.org/10.1107/S2056989024006078)

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Abstract

A new polymorph of the diuretic chlorothiazide, 6-chloro-1,1-dioxo-2H-1,2,4-benzothiazine-7-sulfonamide, C7H6ClN3O4S2, is described. Crystallized from basic aqueous solution, this monoclinic polymorph is found to be less thermodynamically favoured than the known triclinic polymorph and to feature only N—H---O type intermolecular hydrogen bonds as opposed to the N—H---O and N—H---N type hydrogen bonds found in the P1 form.

ORCID iDs

Brydson, Rowan K. H. and Kennedy, Alan R. ORCID logoORCID: https://orcid.org/0000-0003-3652-6015;
CORE (COnnecting REpositories)