Counterion effect in cobaltate-catalyzed alkene hydrogenation

Gawron, Martin and Gilch, Franziska and Schmidhuber, Daniel and Kelly, John A. and Horsley Downie, Thomas M. and Jacobi von Wangelin, Axel and Rehbein, Julia and Wolf, Robert (2024) Counterion effect in cobaltate-catalyzed alkene hydrogenation. Angewandte Chemie International Edition, 63 (6). e202315381. ISSN 1521-3773 (https://doi.org/10.1002/anie.202315381)

[thumbnail of Gawron-etal-ACIE-2024-Couterion-effect-in-cobaltate-catalyzed]
Preview
 Text. Filename: Gawron-etal-ACIE-2024-Couterion-effect-in-cobaltate-catalyzed.pdf
Final Published Version
License: Creative Commons Attribution-NonCommercial 4.0 logo
Download (7MB)| Preview

Abstract

We show that countercations exert a remarkable influence on the ability of anionic cobaltate salts to catalyze challenging alkene hydrogenations. An evaluation of the catalytic properties of [Cat][Co(?4-cod)2] (Cat=K (1), Na (2), Li (3), (Depnacnac)Mg (4), and N(nBu)4 (5); cod=1,5-cyclooctadiene, Depnacnac={2,6-Et2C6H3NC(CH3)}2CH)]) demonstrated that the lithium salt 3 and magnesium salt 4 drastically outperform the other catalysts. Complex 4 was the most active catalyst, which readily promotes the hydrogenation of highly congested alkenes under mild conditions. A plausible catalytic mechanism is proposed based on density functional theory (DFT) investigations. Furthermore, combined molecular dynamics (MD) simulation and DFT studies were used to examine the turnover-limiting migratory insertion step. The results of these studies suggest an active co-catalytic role of the counterion in the hydrogenation reaction through the coordination to cobalt hydride intermediates.

ORCID iDs

Gawron, Martin, Gilch, Franziska, Schmidhuber, Daniel, Kelly, John A., Horsley Downie, Thomas M. ORCID logoORCID: https://orcid.org/0000-0001-5027-450X, Jacobi von Wangelin, Axel, Rehbein, Julia and Wolf, Robert;
  • Item type:Article
    ID code:89520
    Dates:
    Date
    Event
    5 February 2024
    Published
    4 January 2024
    Published Online
    7 December 2023
    Accepted
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:07 Jun 2024 16:54
    Last modified:11 Nov 2024 14:21
    URI:https://strathprints.strath.ac.uk/id/eprint/89520
CORE (COnnecting REpositories)