Computational analysis of blood flow in healthy pulmonary arteries in comparison to repaired Tetralogy of Fallot results : a small cohort study

Boumpouli, Maria and Black, Scott MacDonald and Kazakidi, Asimina (2024) Computational analysis of blood flow in healthy pulmonary arteries in comparison to repaired Tetralogy of Fallot results : a small cohort study. Fluids, 9 (4). 85. ISSN 2311-5521 (https://doi.org/10.3390/fluids9040085)

[thumbnail of Boumpouli-etal-Fluids-2024-Computational-analysis-of-blood-flow-in-healthy-pulmonary-arteries-in-comparison-to-repaired-Tetralogy-of-Fallot]
Preview
 Text. Filename: Boumpouli-etal-Fluids-2024-Computational-analysis-of-blood-flow-in-healthy-pulmonary-arteries-in-comparison-to-repaired-Tetralogy-of-Fallot.pdf
Final Published Version
License: Creative Commons Attribution 4.0 logo
Download (5MB)| Preview

Abstract

Characterization of the physiological hemodynamic environment in normal pulmonary arteries is a key factor in understanding pathological conditions. This study aimed to analyze the morphology and hemodynamics in the healthy adult pulmonary bifurcation in comparison to age-matched repaired Tetralogy of Fallot (rTOF) geometries. The pulmonary trunk of five healthy volunteers was reconstructed from 4D Flow-MRI data and was compared to rTOF results. Subject-specific boundary conditions were assigned in both the inlet and outlets of the models, and flow characteristics were analyzed computationally. The morphological and flow features were consistent among the healthy geometries, highlighting the ability of an averaged geometry derived from this small cohort to capture the main flow characteristics. A slightly higher mean time-averaged wall shear stress (TAWSS) was found in the right pulmonary artery, which was also the branch with a higher mean curvature and local Reynolds number. Compared to rTOF results, the averaged healthy geometry demonstrated more than an 8-fold lower value in TAWSS, with the individual patient-specific healthy volunteers showing further reduced TAWSS than the rTOF patients. These observations could be useful in clinical assessment and decision making based on hemodynamic indices.

  • Item type:Article
    ID code:88597
    Dates:
    Date
    Event
    1 April 2024
    Published
    22 March 2024
    Accepted
    9 February 2024
    Submitted
    Subjects:Medicine
    Department:Faculty of Engineering > Biomedical Engineering
    Depositing user: Pure Administrator
    Date deposited:03 Apr 2024 07:06
    Last modified:20 Apr 2024 00:52
    URI:https://strathprints.strath.ac.uk/id/eprint/88597
CORE (COnnecting REpositories)