Evidence of objective sleep impairment in nonepileptic attack disorder : a naturalistic prospective controlled study using actigraphy and daily sleep diaries over six nights

Mousa, Saafi and Latchford, Gary and Weighall, Anna and Nash, Hannah and Murray-Leslie, Rebecca and Reuber, Markus and Relton, Samuel D. and Graham, Christopher D. (2021) Evidence of objective sleep impairment in nonepileptic attack disorder : a naturalistic prospective controlled study using actigraphy and daily sleep diaries over six nights. Epilepsy and Behavior, 117. 107867. ISSN 1525-5069 (https://doi.org/10.1016/j.yebeh.2021.107867)

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Abstract

Poor sleep is reported by many with nonepileptic attack disorder (NEAD) with correlations evident between self-reported sleep quality and mood and functional impairment. However, it is contended that self-reported sleep impairment in NEAD is a subjective phenomenon, which represents a general tendency to over-report symptoms or misinterpret bodily states in those with NEAD. The present study was therefore designed to investigate the extent of subjective and objective sleep impairments in those with NEAD. Over six nights we prospectively recorded comparable nightly objective (actigraphy) and subjective (consensus sleep diary) sleep parameters in a sample of 17 people with NEAD, and an age- and gender-matched normative control group (N = 20). Participants recorded daily measures of attacks, dissociation, and mood. Alongside higher subjective sleep impairment, the NEAD group had significantly worse objective sleep on several metrics compared to the normative controls, characterized by disrupted sleep (frequent awakenings and wake after sleep onset, low efficiency). Exploratory analyses using mixed effects models showed that attacks were more likely to occur on days preceded by longer, more restful sleep. This study, which had good ecological validity, evidences the presence of objective sleep impairment in NEAD, suggesting that in patient reports of problems with sleep should be given careful consideration in clinical practice.

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