Biological ammonium transporters : evolution and diversification
Williamson, Gordon and Harris, Thomas and Bizior, Adriana and Hoskisson, Paul Alan and Pritchard, Leighton and Javelle, Arnaud (2024) Biological ammonium transporters : evolution and diversification. FEBS Journal, 291 (17). pp. 3786-3810. ISSN 1742-464X (https://doi.org/10.1111/febs.17059)
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Abstract
Although ammonium is the preferred nitrogen source for microbes and plants, in animal cells it is a toxic product of nitrogen metabolism that needs to be excreted. Thus, ammonium movement across biological membranes, whether for uptake or excretion, is a fundamental and ubiquitous biological process catalysed by the superfamily of the Amt/Mep/Rh transporters. A remarkable feature of the Amt/Mep/Rh family is that they are ubiquitous and, despite sharing low amino acid sequence identity, are highly structurally conserved. Despite sharing a common structure, these proteins have become involved in a diverse range of physiological process spanning all domains of life, with reports describing their involvement in diverse biological processes being published regularly. In this context, we exhaustively present their range of biological roles across the domains of life and after explore current hypotheses concerning their evolution to help to understand how and why the conserved structure fulfils diverse physiological functions.
ORCID iDs
Williamson, Gordon, Harris, Thomas, Bizior, Adriana, Hoskisson, Paul Alan ORCID: https://orcid.org/0000-0003-4332-1640, Pritchard, Leighton ORCID: https://orcid.org/0000-0002-8392-2822 and Javelle, Arnaud ORCID: https://orcid.org/0000-0002-3611-5737;-
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Item type: Article ID code: 88191 Dates: DateEvent1 September 2024Published24 January 2024Published Online9 January 2024Accepted14 December 2023SubmittedSubjects: Science > Natural history > Biology Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 15 Feb 2024 10:26 Last modified: 11 Nov 2024 14:11 URI: https://strathprints.strath.ac.uk/id/eprint/88191