Influence of food on paediatric gastrointestinal drug absorption following oral administration : a review
Batchelor, Hannah K. (2015) Influence of food on paediatric gastrointestinal drug absorption following oral administration : a review. Children, 2 (2). pp. 244-271. ISSN 2227-9067 (https://doi.org/10.3390/children2020244)
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Abstract
The objective of this paper was to review existing information regarding food effects on drug absorption within paediatric populations. Mechanisms that underpin food–drug interactions were examined to consider potential differences between adult and paediatric populations, to provide insights into how this may alter the pharmacokinetic profile in a child. Relevant literature was searched to retrieve information on food–drug interaction studies undertaken on: (i) paediatric oral drug formulations; and (ii) within paediatric populations. The applicability of existing methodology to predict food effects in adult populations was evaluated with respect to paediatric populations where clinical data was available. Several differences in physiology, anatomy and the composition of food consumed within a paediatric population are likely to lead to food–drug interactions that cannot be predicted based on adult studies. Existing methods to predict food effects cannot be directly extrapolated to allow predictions within paediatric populations. Development of systematic methods and guidelines is needed to address the general lack of information on examining food–drug interactions within paediatric populations.
ORCID iDs
Batchelor, Hannah K. ORCID: https://orcid.org/0000-0002-8729-9951;-
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Item type: Article ID code: 88154 Dates: DateEvent9 June 2015Published18 May 2015AcceptedSubjects: Medicine > Pediatrics Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 13 Feb 2024 11:06 Last modified: 02 Oct 2024 20:08 URI: https://strathprints.strath.ac.uk/id/eprint/88154