Biological ammonium transporters from the Amt/Mep/Rh superfamily : mechanism, energetics, and technical limitations

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Williamson, Gordon and Bizior, Adriana and Harris, Thomas and Pritchard, Leighton and Hoskisson, Paul A. and Javelle, Arnaud (2024) Biological ammonium transporters from the Amt/Mep/Rh superfamily : mechanism, energetics, and technical limitations. Bioscience Reports, 44 (1). BSR20211209. ISSN 1573-4935 (https://doi.org/10.1042/BSR20211209)

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Abstract

The exchange of ammonium across cellular membranes is a fundamental process in all domains of life and is facilitated by the ubiquitous Amt/Mep/Rh transporter superfamily. Remarkably, despite a high structural conservation in all domains of life, these proteins have gained various biological functions during evolution. It is tempting to hypothesise that the physiological functions gained by these proteins may be explained at least in part by differences in the energetics of their translocation mechanisms. Therefore, in this review, we will explore our current knowledge of energetics of the Amt/Mep/Rh family, discuss variations in observations between different organisms, and highlight some technical drawbacks which have hampered effects at mechanistic characterisation. Through the review we aim to provide a comprehensive overview of current understanding of the mechanism of transport of this unique and extraordinary Amt/Mep/Rh superfamily of ammonium transporters.

ORCID iDs

Williamson, Gordon, Bizior, Adriana, Harris, Thomas, Pritchard, Leighton ORCID logoORCID: https://orcid.org/0000-0002-8392-2822, Hoskisson, Paul A. ORCID logoORCID: https://orcid.org/0000-0003-4332-1640 and Javelle, Arnaud ORCID logoORCID: https://orcid.org/0000-0002-3611-5737;
CORE (COnnecting REpositories)