The impact of venepuncture training on the reduction of pre-analytical blood sample haemolysis rates : A systematic review

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Makhumula-Nkhoma, Nellie and Weston, Kathryn L. and McSherry, Robert and Atkinson, Greg (2019) The impact of venepuncture training on the reduction of pre-analytical blood sample haemolysis rates : A systematic review. Journal of Clinical Nursing, 28 (23-24). pp. 4166-4176. ISSN 1365-2702 (https://doi.org/10.1111/jocn.14997)

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Abstract

Background: Venepuncture involves the introduction of a needle into a vein to collect a representative blood sample for laboratory testing. In the pre-analytical phase, haemolysis (the rupturing of erythrocytes and release of their contents into the extracellular compartment) has safety, quality and cost implications. Training in correct venepuncture practice has the potential to reduce in vitro haemolysis rates, but the evidence for this notion has yet to be synthesised. Design: Systematic review (PRISMA Checklist). Methods: Published studies on the effectiveness of venepuncture training on haemolysis rates were searched in relevant databases. The McMaster critical appraisal tool was used to assess methodological quality. The GRADE tool was used to evaluate the body of evidence in relation to the research questions. Implementation fidelity was also scrutinised in each study. Results: Eight out of 437 retrieved studies met the inclusion criteria. None were randomised controlled trials (RCT). Between-study heterogeneity in design, intervention characteristics and the biochemical threshold for haemolysis precluded a meta-analysis. Post-training reductions in haemolysis rates of between 0.4%–19.8% were reported in four of the studies, which developed their intervention according to a clear evidence base and included mentoring in the intervention. Rises in haemolysis rates of between 1.3%–1.9% were reported in two studies, while the intervention effect was inconsistent within two other studies. Conclusion: There are no RCTS on the effectiveness of venepuncture training for reducing haemolysis rates, and findings from the existing uncontrolled studies are unclear. For a more robust evidence base, we recommend more RCTs with standardisation of haemolysis thresholds and training-related factors. Relevance to clinical practice: While venepuncture training is an important factor influencing quality of blood sample in clinical practice, more robust evidence is needed to make specific recommendations about training content for reduction of haemolysis rates. Standardisation of haemolysis thresholds would also enable future meta-analyses.

ORCID iDs

Makhumula-Nkhoma, Nellie, Weston, Kathryn L. ORCID logoORCID: https://orcid.org/0000-0001-5918-6389, McSherry, Robert and Atkinson, Greg;
  • Item type:Article
    ID code:87637
    Dates:
    Date
    Event
    1 December 2019
    Published
    11 July 2019
    Published Online
    21 June 2019
    Accepted
    28 February 2019
    Submitted
    Notes:Publisher Copyright: © 2019 John Wiley & Sons Ltd Makhumula‐Nkhoma N, Weston KL, McSherry R, Atkinson G. The impact of venepuncture training on the reduction of pre‐analytical blood sample haemolysis rates: A systematic review. J Clin Nurs. 2019;28:4166–4176. https ://doi.org/10.1111/jocn.14997
    Subjects:Medicine
    Department:Faculty of Humanities and Social Sciences (HaSS) > Psychological Sciences and Health > Physical Activity for Health
    Depositing user: Pure Administrator
    Date deposited:14 Dec 2023 15:52
    Last modified:02 Dec 2024 01:29
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/87637
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