Antibiotic resistance patterns in soils across the Scottish landscape
Pagaling, Eulyn and Hough, Rupert and Avery, Lisa and Robinson, Lucinda and Freitag, Thomas and Coull, Malcolm and Zhou, Xinyuan and Su, Jian-Qiang and Peshkur, Tatyana and Zhu, Yong-Guan and Graham, David W. and Knapp, Charles W. (2023) Antibiotic resistance patterns in soils across the Scottish landscape. Communications Earth & Environment, 4 (1). 403. ISSN 2662-4435 (https://doi.org/10.1038/s43247-023-01057-0)
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Abstract
The environment disseminates antimicrobial-resistance genes; however, it remains challenging to distinguish whether human activities exacerbate antimicrobial resistance or what is natural. Here, we quantified ~300 resistance-related genes in 200+ Scottish soil samples. Location or land use does not explain gene differences, but nutrient levels reduce gene richness. Elevated levels of metals increased gene richness, and selenium increased transposase levels. Rainfall and persistent organic pollutants also increased transposase relative abundance, possibly promoting conditions conducive to the horizontal transfer of antimicrobial-resistance genes. Selenium and polychlorinated biphenyls were primary factors in gene abundance, while polychlorinated biphenyls, polycyclic aromatic hydrocarbons, and pH influenced gene diversity. Polychlorinated biphenyls are derived from anthropogenic activities, highlighting human activities’ potential impact on gene prevalence. This is the first national-scale, high spatial resolution dataset of antimicrobial-resistance genes in Scottish soils and provides a novel resource on which to build future studies.
ORCID iDs
Pagaling, Eulyn, Hough, Rupert, Avery, Lisa, Robinson, Lucinda, Freitag, Thomas, Coull, Malcolm, Zhou, Xinyuan, Su, Jian-Qiang, Peshkur, Tatyana, Zhu, Yong-Guan, Graham, David W. and Knapp, Charles W. ORCID: https://orcid.org/0000-0001-7997-8543;-
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Item type: Article ID code: 87151 Dates: DateEvent1 November 2023Published18 October 2023Accepted12 April 2023SubmittedSubjects: Technology > Engineering (General). Civil engineering (General) > Environmental engineering Department: Faculty of Engineering > Civil and Environmental Engineering Depositing user: Pure Administrator Date deposited: 03 Nov 2023 09:16 Last modified: 29 Oct 2024 01:45 URI: https://strathprints.strath.ac.uk/id/eprint/87151