Morphological characterisation of pediatric turner syndrome aortae : insights from a small cohort study
Johnston, Lauren and Allen, Ruth and Mason, Avril and Kazakidi, Asimina (2023) Morphological characterisation of pediatric turner syndrome aortae : insights from a small cohort study. Medical Engineering and Physics, 120. 104045. ISSN 1873-4030 (https://doi.org/10.1016/j.medengphy.2023.104045)
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Abstract
Cardiovascular disease is widespread in girls and women living with Turner syndrome (TS). Despite this prevalence, cardiovascular risk evaluation using the current guidelines has seen life-threatening aortic events occurring at dimensions classified within the normal threshold. In this study, we characterized the three-dimensional aortic geometries of Turner syndrome children and their age-matched healthy counterparts to evaluate various morphological parameters. Turner syndrome girls had overall greater values in ten out of fifteen parameters examined (p > 0.05), when compared to healthy children: the aortic arch height and width; the ascending aorta, aortic arch (2 locations), and descending aorta diameters; the ratio of the ascending to descending aorta diameter; average curvature; average torsion; and average curvature-torsion score. Additionally, significant associations were found in the TS group: body surface area and both arch height (p = 0.03) and arch height to width ratio (p = 0.05), and aortic arch diameter and both body surface area(p = 0.04) and weight (p = 0.04). The new information resulting from this small cohort study contributes to an improved understanding of the morphological parameters affecting the hemodynamic environment in TS, and the clinical assessment of the increased cardiovascular risk in this population.
ORCID iDs
Johnston, Lauren, Allen, Ruth, Mason, Avril and Kazakidi, Asimina ORCID: https://orcid.org/0000-0001-7124-4123;-
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Item type: Article ID code: 86578 Dates: DateEvent31 October 2023Published9 September 2023Published Online28 August 2023Accepted19 January 2023SubmittedSubjects: Medicine > Pediatrics Department: Faculty of Engineering > Biomedical Engineering Depositing user: Pure Administrator Date deposited: 28 Aug 2023 14:57 Last modified: 26 Oct 2024 10:41 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/86578