Glass microparticle- versus microsphere-filled experimental dental adhesives

Abou Neel, Ensanya A. and Kiani, Azadeh and Valappil, Sabeel P. and Mordan, Nicky M. and Baek, Song-Yi and Zakir Hossain, Kazi M. and Felfel, Reda M. and Ahmed, Ifty and Divakarl, Kamini and Chrzanowski, Wojciech and Knowles, Jonathan C. (2019) Glass microparticle- versus microsphere-filled experimental dental adhesives. Journal of Applied Polymer Science, 136 (32). 47832. ISSN 0021-8995 (https://doi.org/10.1002/app.47832)

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Abstract

This study aimed to formulate antibacterial dental adhesives. Phosphate-substituted methacrylate adhesives were modified with 0–20 wt % copper-doped glass microparticles. Two shapes of microparticles were used: regular shaped (microspheres) and irregular shaped (microparticles). The morphology/composition, roughness, monomer conversion (DC%), thermogravimetric analysis, and antibacterial action against S. mutans and P. aeruginosa and ion release were investigated. The results showed that microspheres produced adhesives with a relatively smoother surface than microparticles did. The DC% of adhesives increased with increasing glass filler content. Filled adhesives showed polymer decomposition at ~315 °C and glass melting at 600–1000 °C. The weight loss percent of adhesives decreased with increasing weight percent of fillers. Glass microparticles at 0–20 wt % significantly increased the antibacterial action of adhesives against both bacteria. Glass microspheres at 0–5 wt % significantly increased the antibacterial action of adhesives against both bacteria. Only 20 wt % microparticle-filled adhesive showed an inhibition zone similar to tobramycin (positive control). Microparticle-filled adhesives (with >5 wt % filler) significantly reduced S. mutans more than their microsphere counterparts. Microsphere-filled adhesives (with ≤5 wt % filler) significantly reduced P. aeruginosa more than their microparticle counterparts. Microsphere-filled adhesives showed higher Cu release than their microparticle counterparts. Accordingly, phosphate-substituted methacrylate filled with glass could be used as an antibacterial adhesive.

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