Iatrogenic copper deficiency : risks and cautions with zinc prescribing
Duncan, Andrew and Morrison, Ian and Bryson, Scott (2023) Iatrogenic copper deficiency : risks and cautions with zinc prescribing. British Journal of Clinical Pharmacology, 89 (9). pp. 2825-2829. ISSN 0306-5251 (https://doi.org/10.1111/bcp.15749)
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Abstract
Aims Copper deficiency resulting from prescribing zinc in high doses is a rare but life-changing diagnosis that is frequently overlooked. The aim of this study is to gauge how often zinc-induced copper deficiency is missed, to raise awareness of the condition and to stress the need for guidelines for prescribing zinc. Methods Suspected cases of zinc-induced copper deficiency were retrospectively obtained by selecting those patients with hyperzincaemia and hypocupraemia from the database of the Scottish Trace Element Laboratory. Case records were reviewed to determine the validity of the suspected diagnosis. Results After exclusions, 23 instances of high serum zinc and low serum copper concentrations were found. A positive diagnosis of zinc-induced copper deficiency was made in 14 patients of which 7 (50%) were previously undiagnosed. Conclusion Serum zinc and copper concentrations are rarely measured in patients prescribed zinc and so the vast majority of cases of zinc-induced copper deficiency are likely to be undiagnosed. We recommend the current official advice on the dose and frequency of zinc administration is revised in order to limit, and potentially eradicate, the condition.
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Item type: Article ID code: 85381 Dates: DateEvent30 September 2023Published17 April 2023Published Online21 February 2023AcceptedSubjects: Medicine > Therapeutics. Pharmacology
Medicine > Pharmacy and materia medica > Pharmaceutical chemistryDepartment: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 03 May 2023 15:34 Last modified: 30 Sep 2024 00:33 URI: https://strathprints.strath.ac.uk/id/eprint/85381