Phenolic compounds as Nrf2 inhibitors : potential applications in cancer therapy

Sharifi-Rad, Javad and Seidel, Veronique and Izabela, Michalak and Monserrat-Mequida, Margalida and Sureda, Antoni and Ormazabal, Valeska and Zuniga, Felipe A. and Mangalpady, Shivaprasad Shetty and Pezzani, Raffaele and Ydyrys, Alibek and Tussupbekova, Gulmira and Martorell, Miquel and Calina, Daniela and Cho, William C. (2023) Phenolic compounds as Nrf2 inhibitors : potential applications in cancer therapy. Cell Communication and Signalling, 21. 89. ISSN 1478-811X (https://doi.org/10.1186/s12964-023-01109-0)

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Abstract

Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has a crucial role in cytoprotective response against oxidative stress, including cancer growth and progression and therapy resistance. For this reason, inhibitors of Nrf2 are new targets to be studied. Traditional plant-based remedies rich in phytochemicals have been used against human cancers and phenolic compounds are known for their chemopreventive properties. This comprehensive review offers an updated review of the role of phenolic compounds as anticancer agents due to their action on Nrf2 inhibition. In addition, the role of naturally-occurring bioactive anticancer agents are covered in the clinical applications of polyphenols as Nrf2 inhibitors. EkynToSR555mbd1vVCBd11Video Abstract

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