Peptides, proteins and antibodies

Iellamo De Gennaro, Santina and Lalatsa, Aikaterini; Uchegbu, Ijeoma F. and Schatzlein, Andreas G., eds. (2024) Peptides, proteins and antibodies. In: Fundamentals of Pharmaceutical Nanoscience. Springer Publishing, New York, NY. ISBN 9783031594779 (In Press)

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Abstract

Peptide and protein therapeutics are an area of continuous market growth and able to address a growing range of clinical pathologies due to their high specificity and potency combined with low toxicity of metabolic products and minimal potential for drug–drug interactions, which make them attractive candidates for clinical development. The pharmaceutical industry is today more in need of delivery technologies either as engineering peptide prodrugs/chimeras by appending a peptide/protein domain to a therapeutic protein to target or able to bind a particular receptor combined potentially with a material strategy (nano-enabled delivery systems or devices) for delivery via non-parenteral routes. In this chapter, the strategies able to deliver peptide or protein therapeutics via controlled delivery parenteral strategies but also oral and nasal routes and their applications will be discussed.

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