Flying spot en face OCT for monitoring cell distribution in collagen-based constructs

Kosmidis, K. and Russell, Christopher D. and Dobre, George and Podoleanu, Adrian Gh. and Black, R.A. (2007) Flying spot en face OCT for monitoring cell distribution in collagen-based constructs. Multiphoton Microscopy in the Biomedical Sciences IV (Proceedings of SPIE), 6079. 60790Q-1. ISSN 1605-7422 (http://dx.doi.org/10.1089/ten.2007.1501)

Abstract

The use of optical coherence tomography (OCT) as a monitoring tool in the growth of human fibroblasts cells in collagen-based constructs is investigated. Rat-tail tendon type-1 collagen based gels mixed with human fibroblasts were prepared and incubated. Fixed samples were then imaged using OCT, and subsequently cross-sectioned and analysed microscopically. The concentration of cells in samples under different contraction dynamics was investigated using analysis of the OCT images. Results show clear differences in scattering intensity as a consequence of cell concentration in both OCT images and micrographs.

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• Item metadata

  Item type:	Article
  ID code:	8331
  Dates:	Date Event 2007 Published
  Notes:	Biomedical Optics Conference, San Jose, 21-26 Jan. 2006 Progress in Biomedical Optics and Imaging, Vol. 7, No. 2, 2006
  Subjects:	Technology > Engineering (General). Civil engineering (General) > Bioengineering Science > Physiology
  Department:	Faculty of Engineering > Bioengineering
  Depositing user:	Strathprints Administrator
  Date deposited:	04 Aug 2009 14:33
  Last modified:	11 Nov 2024 09:00
  URI:	https://strathprints.strath.ac.uk/id/eprint/8331