A study of the reactivity of cyclic aminomethylammonium mannich salts

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Dimitrova, Daniela and McMahon, Connor and Kennedy, Alan R. and Parkinson, John A. and Leach, Stuart G. and Boulton, Lee T. and Pascoe, David D. and Murphy, John A. (2022) A study of the reactivity of cyclic aminomethylammonium mannich salts. Tetrahedron, 128. 133120. ISSN 0040-4020 (https://doi.org/10.1016/j.tet.2022.133120)

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Abstract

A novel method for the preparation of aminoalkylaminomethyl products was developed utilising novel Mannich-type salts featuring a R 2NCH 2NR 3 + moiety. This methodology showed good nucleophile scope and was successfully employed in reactions under basic, acidic, and neutral conditions. A wide range of diamine products was successfully synthesised, including a neuropeptide Y antagonist.

ORCID iDs

Dimitrova, Daniela, McMahon, Connor, Kennedy, Alan R. ORCID logoORCID: https://orcid.org/0000-0003-3652-6015, Parkinson, John A. ORCID logoORCID: https://orcid.org/0000-0003-4270-6135, Leach, Stuart G., Boulton, Lee T., Pascoe, David D. and Murphy, John A.;
  • Item type:Article
    ID code:83293
    Dates:
    Date
    Event
    3 December 2022
    Published
    5 November 2022
    Published Online
    27 October 2022
    Accepted
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:22 Nov 2022 14:41
    Last modified:23 Nov 2024 02:56
    URI:https://strathprints.strath.ac.uk/id/eprint/83293
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