A study of the reactivity of cyclic aminomethylammonium mannich salts

Dimitrova, Daniela and McMahon, Connor and Kennedy, Alan R. and Parkinson, John A. and Leach, Stuart G. and Boulton, Lee T. and Pascoe, David D. and Murphy, John A. (2022) A study of the reactivity of cyclic aminomethylammonium mannich salts. Tetrahedron, 128. 133120. ISSN 0040-4020 (https://doi.org/10.1016/j.tet.2022.133120)

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Abstract

A novel method for the preparation of aminoalkylaminomethyl products was developed utilising novel Mannich-type salts featuring a R 2NCH 2NR 3 + moiety. This methodology showed good nucleophile scope and was successfully employed in reactions under basic, acidic, and neutral conditions. A wide range of diamine products was successfully synthesised, including a neuropeptide Y antagonist.

ORCID iDs

Dimitrova, Daniela, McMahon, Connor, Kennedy, Alan R. ORCID logoORCID: https://orcid.org/0000-0003-3652-6015, Parkinson, John A. ORCID logoORCID: https://orcid.org/0000-0003-4270-6135, Leach, Stuart G., Boulton, Lee T., Pascoe, David D. and Murphy, John A.;
  • Item type:Article
    ID code:83293
    Dates:
    Date
    Event
    3 December 2022
    Published
    5 November 2022
    Published Online
    27 October 2022
    Accepted
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:22 Nov 2022 14:41
    Last modified:11 Nov 2024 13:41
    URI:https://strathprints.strath.ac.uk/id/eprint/83293
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