Multiplexed profiling of extracellular vesicles for biomarker development

Jiang, Cheng and Fu, Ying and Liu, Guozhen and Shu, Bowen and Davis, Jason and Tofaris, George K. (2021) Multiplexed profiling of extracellular vesicles for biomarker development. Nano-Micro Letters. ISSN 2311-6706 (https://doi.org/10.1007/s40820-021-00753-w)

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Abstract

Extracellular vesicles (EVs) are cell-derived membranous particles that play a crucial role in molecular trafficking, intercellular transport and the egress of unwanted proteins. They have been implicated in many diseases including cancer and neurodegeneration. EVs are detected in all bodily fluids, and their protein and nucleic acid content offers a means of assessing the status of the cells from which they originated. As such, they provide opportunities in biomarker discovery for diagnosis, prognosis or the stratification of diseases as well as an objective monitoring of therapies. The simultaneous assaying of multiple EV-derived markers will be required for an impactful practical application, and multiplexing platforms have evolved with the potential to achieve this. Herein, we provide a comprehensive overview of the currently available multiplexing platforms for EV analysis, with a primary focus on miniaturized and integrated devices that offer potential step changes in analytical power, throughput and consistency.

ORCID iDs

Jiang, Cheng, Fu, Ying ORCID logoORCID: https://orcid.org/0000-0002-8196-6493, Liu, Guozhen, Shu, Bowen, Davis, Jason and Tofaris, George K.;
  • Item type:Article
    ID code:83057
    Dates:
    Date
    Event
    2 December 2021
    Published
    2 December 2021
    Published Online
    22 October 2021
    Accepted
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:03 Nov 2022 11:35
    Last modified:14 Nov 2024 02:22
    URI:https://strathprints.strath.ac.uk/id/eprint/83057
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