Memory-driven eye movements prospectively predict dementia in people at risk of Alzheimer's disease
Parra, Mario A and Juan Granada, Juan and Fernández, Gerardo (2022) Memory-driven eye movements prospectively predict dementia in people at risk of Alzheimer's disease. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 14 (1). e12386. ISSN 2352-8729 (https://doi.org/10.1002/dad2.12386)
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Abstract
INTRODUCTION: Oculomotor behaviors linked to cognitive performance revealed neurocognitive features of AD that can enhance the accuracy of its assessment and diagnosis. METHODS: A sample of 107 participants (i.e., 65 MCI and 42 controls) were recruited and followed up for 40 months. At baseline, they underwent assessment with the ViewMind digital biomarker, which draws cognitive related patterns of eye movement while people perform the Visual Short-Term Memory Binding task. RESULTS: Baseline data predicted that 36 MCI patients would progress to the AD clinical syndrome (ADS, AD Progressing). The remaining 29 MCI patients were predicted to remain as MCI or progress to other forms of dementia. After 40-months of follow up, 94% of ADS Progressing patients had received a diagnosis of dementia where none of the non-ADS Progressing had. DISCUSSION: The analysis of eye movement behavior combined with cognitive markers for AD can effectively predict progression to ADS among patients with MCI.
ORCID iDs
Parra, Mario A ORCID: https://orcid.org/0000-0002-2412-648X, Juan Granada, Juan and Fernández, Gerardo;-
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Item type: Article ID code: 82889 Dates: DateEvent22 December 2022Published21 October 2022Accepted16 June 2022SubmittedSubjects: Medicine > Internal medicine > Neuroscience. Biological psychiatry. Neuropsychiatry Department: Faculty of Humanities and Social Sciences (HaSS) > Psychological Sciences and Health > Psychology Depositing user: Pure Administrator Date deposited: 24 Oct 2022 09:21 Last modified: 12 Dec 2024 13:27 URI: https://strathprints.strath.ac.uk/id/eprint/82889