Neutrophil to lymphocyte ratio and in-hospital mortality among patients with SARSCoV-2 : a retrospective study

Al-Mazedi, Maryam Salah and Rajan, Rajesh and Al-Jarallah, Mohammed and Dashti, Raja and Al Saber, Ahmad and Pan, Jiazhu and Zhanna, Kobalava D. and Abdelnaby, Hassan and Aboelhassan, Wael and Almutairi, Farah and Alotaibi, Naser and Al Saleh, Mohammad and AlNasrallah, Noor and Al-Bader, Bader and Malhas, Haya and Ramadhan, Maryam and A. Brady, Peter and Al-Zakwani, Ibrahim and Setiya, Parul and Abdullah, Mohammed and Alroomi, Moudhi and Tse, Gary (2022) Neutrophil to lymphocyte ratio and in-hospital mortality among patients with SARSCoV-2 : a retrospective study. Annals of Medicine and Surgery, 82. 104748. ISSN 2049-0801 (

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The goal of this study was to investigate in-hospital mortality in patients suffering from acute respiratory syndrome coronavirus 2 (SARS-CoV-2) relative to the neutrophil to lymphocyte ratio (NLR) and to determine if there are gender disparities in outcome. Between February 26 and September 8, 2020, patients having SARS-CoV-2 infection were enrolled in this retrospective cohort research, which was categorized by NLR levels ≥9 and < 9. In total, 6893 patients were involved included of whom6591 had NLR <9, and 302 had NLR ≥9. The age of most of the patients in the NLR<9 group was 50 years, on the other hand, the age of most of the NLR ≥9 group patients was between 50 and 70 years. The majority of patients in both groups were male 2211 (66.1%). The ICU admission time and mortality rate for the patients with NLR ≥9 was significantly higher compared to patients with NLR <9. Logistic regression's outcome indicated that NLR ≥9 (odds ratio (OR), 24.9; 95% confidence interval (CI): 15.5–40.0; p < 0.001), male sex (OR, 3.5; 95% CI: 2.0–5.9; p < 0.001) and haemoglobin (HB) (OR, 0.95; 95% CI; 0.94–0.96; p < 0.001) predicted in-hospital mortality significantly. Additionally, Cox proportional hazards analysis (B = 4.04, SE = 0.18, HR = 56.89, p < 0.001) and Kaplan–Meier survival probability plots also indicated that NLR>9 had a significant effect on mortality. NLR ≥9 is an independent predictor of mortality(in-hospital) among SARS-CoV-2 patients.