Multifunctional peptide biointerfaces

Lau, King Hang Aaron and Pandey, Lalit M. and Saxena, Varun and Mukhtar, Asma; Elsawy, Mohamed, ed. (2022) Multifunctional peptide biointerfaces. In: Peptide Bionanomaterials. Springer-Verlag, Heidelberg, Germany. (In Press)

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In creating useful devices for biomedical and other applications that come into contact with bi-ological fluids, it is of great interest to mimic the multifaceted control of complex biomolecular and cell interactions observed in nature. On the molecular level, all such interactions involve surfaces and interfaces. In biology, this is often a cell membrane interface. In devices, this is the surface or interface of an artificial material, be it a nanoparticle or the surface of a bio-material or biosensor. Multifunctional biointerfaces aim to provide simultaneous modulation of several biological signals. This chapter highlights the use of both linear and multi-armed peptide designs specifically conceived for such multifunctional surface applications. As shown by the studies reviewed, this dedicated strategy has met with considerable success, not least because even relatively short oligopeptide sequences, including cell-instructive and anti-microbial motifs, are being shown to be capable of diverse and robust bioactivities. Moreover, these sequences (and related peptidomimics) may be rationally combined and conveniently synthesized by standardized solid phase peptide synthesis. In addition, research into multi-functional peptide biointerfaces has been greatly aided by advances in simple and facile sur-face immobilization chemistries (e.g. SAMs and DOPA/polydopamine), as well as the realiza-tion that proteins possess native “antifouling” properties that can be mimicked by simple and mostly zwitterionic residue compositions to suppress non-specific interactions and enhance biorecognition binding. Overall, functionalization of biointerfaces with multifunctional pep-tides stands out as a powerful strategy to engineer protein-mimetic bioactivity on artificial ma-terials and device surfaces, and great scope remains for the development of applications based on even more diverse peptide architectures as well as expanded range of protein-mimetic bio-recognition and multifunctionality.


Lau, King Hang Aaron ORCID logoORCID:, Pandey, Lalit M., Saxena, Varun and Mukhtar, Asma; Elsawy, Mohamed