A national, multicentre web-based point prevalence survey of antimicrobial use in community healthcare centres across South Africa and the implications

Tools

Skosana, Phumzile P and Schellack, Natalie and Godman, Brian and Kurdi, Amanj and Bennie, Marion and Kruger, Danie and Meyer, Johanna C (2022) A national, multicentre web-based point prevalence survey of antimicrobial use in community healthcare centres across South Africa and the implications. Hospital Practice, 50 (4). pp. 306-317. ISSN 2377-1003 (https://doi.org/10.1080/21548331.2022.2114251)

[thumbnail of Skosana-etal-HP-2022-Multicentre-web-based-point-prevalence-survey-of-antimicrobial]
Preview
 Text. Filename: Skosana_etal_HP_2022_Multicentre_web_based_point_prevalence_survey_of_antimicrobial.pdf
Final Published Version
License: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 logo
Download (328kB)| Preview

Abstract

Objective: Up to 90% of antimicrobials globally are prescribed and dispensed in ambulatory care. However, there are considerable gaps regarding the extent and rationale for their use especially in low- and middle-income countries such as South Africa. Point prevalent surveys (PPS) are useful to determine current prescribing patterns, identify targets for quality improvement and evaluate the effectiveness of antimicrobial stewardship programmes (ASPs) within institutions. Consequently, the objective of this study was to undertake a PPS within community health centres (CHCs) in South Africa given their importance to the public healthcare system. The findings will be used to provide guidance on future interventions to improve antimicrobial use in South Africa and wider. Methods: A PPS of antimicrobial consumption was undertaken among patients attending 18 CHCs in South Africa. A web-based application was used to record the utilisation data, with utilisation assessed against World Health Organization (WHO) and South African guidelines. Results: The overall prevalence of antimicrobial use amongst patients attending the CHCs was 21.5% (420 of 1958 patients). This included one or more antimicrobials per patient. The most frequently prescribed antimicrobials were amoxicillin (32.9%), isoniazide (11.3%) and a combination of rifampicin, isoniazid, pyrazinamide and ethambutol (Rifafour®) (10.5%), with the majority from the WHO Access list of antibiotics. There was high adherence to guidelines (93.4%). The most common indication for antibiotics were ear, nose and throat infections (22.8%), with no culture results recorded in patients’ files. Conclusions: It’s encouraging to see high adherence to South African guidelines when antimicrobials were prescribed, with the majority taken from the WHO Access list. However, there were concerns with appreciable prescribing of antimicrobials for upper respiratory tract infections that are essentially viral in origin, and a lack of microbiological testing. The establishment of ASPs can help address identified concerns through designing and implementing appropriate interventions.

ORCID iDs

Skosana, Phumzile P, Schellack, Natalie, Godman, Brian, Kurdi, Amanj ORCID logoORCID: https://orcid.org/0000-0001-5036-1988, Bennie, Marion ORCID logoORCID: https://orcid.org/0000-0002-4046-629X, Kruger, Danie and Meyer, Johanna C;
CORE (COnnecting REpositories)