Modelling the swelling of pharmaceutical tablets from single particle understanding using DEM

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Soundaranathan, Mithushan and Al-Sharabi, Mohammed and Sweijen, Thomas and Pitt, Kendal and Zeitler, J. Axel and Hassanizadeh, S Majid and Johnston, Blair and Markl, Daniel (2022) Modelling the swelling of pharmaceutical tablets from single particle understanding using DEM. In: CMAC Annual Open Day 2022, 2022-05-16 - 2022-05-18.

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Abstract

Most tablets are designed to break up into smaller fragments when they come in contact with a physiological fluid in order to accelerate the dissolution of the drug. This break up is caused by the swelling of individual particles in a tablet that leads to the interruption of the interparticulate bonds. This study focused on modelling the swelling of a tablet using discrete element modelling (DEM) paired with a single particle swelling model [1,2] and experimental liquid penetration depth data measured by a flow through cell [3] coupled with a commercial terahertz (THz) system (TeraPulse 4000, Teraview Ltd., UK).

ORCID iDs

Soundaranathan, Mithushan, Al-Sharabi, Mohammed, Sweijen, Thomas, Pitt, Kendal, Zeitler, J. Axel, Hassanizadeh, S Majid, Johnston, Blair ORCID logoORCID: https://orcid.org/0000-0001-9785-6822 and Markl, Daniel ORCID logoORCID: https://orcid.org/0000-0003-0411-733X;

Persistent Identifier

https://doi.org/10.17868/strath.00081762
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