Individually addressable multi-nanopores for single-molecule targeted operations

Cadinu, Paolo and Kang, Minkyung and Paulose Nadappuram, Binoy and Ivanov, Aleksander P. and Edel, Joshua B. (2020) Individually addressable multi-nanopores for single-molecule targeted operations. Nano Letters, 20 (3). pp. 2012-2019. ISSN 1530-6992 (https://doi.org/10.1021/acs.nanolett.9b05307)

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Abstract

The fine-tuning of molecular transport is a ubiquitous problem of single-molecule methods. The latter is evident even in powerful single-molecule techniques such as nanopore sensing, where the quest for resolving more detailed biomolecular features is often limited by insufficient control of the dynamics of individual molecules within the detection volume of the nanopore. In this work, we introduce and characterize a reconfigurable multi-nanopore architecture that enables additional channels to manipulate the dynamics of DNA molecules in a nanopore. We show that the fabrication process of this device, consisting of four adjacent, individually addressable nanopores located at the tip of a quartz nanopipette, is fast and highly reproducible. By individually tuning the electric field across each nanopore, these devices can operate in several unique cooperative detection modes that allow moving, sensing, and trapping of DNA molecules with high efficiency and increased temporal resolution.

  • Item type:Article
    ID code:81631
    Dates:
    Date
    Event
    11 March 2020
    Published
    13 February 2020
    Published Online
    10 February 2020
    Accepted
    Notes:© 2020 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Nano letters, after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.nanolett.9b05307
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:29 Jul 2022 13:24
    Last modified:20 Apr 2024 22:07
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/81631
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