Disinfector‐assisted low temperature reduced graphene oxide‐protein surgical dressing for the postoperative photothermal treatment of melanoma

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Wu, Yuanhao and Yang, Junyao and van Teijlingen, Alexander and Berardo, Alice and Corridori, Ilaria and Feng, Jingyu and Xu, Jing and Titirici, Maria‐Magdalena and Rodriguez‐Cabello, Jose Carlos and Pugno, Nicola M and Sun, Jiaming and Wang, Wen and Tuttle, Tell and Mata, Alvaro (2022) Disinfector‐assisted low temperature reduced graphene oxide‐protein surgical dressing for the postoperative photothermal treatment of melanoma. Advanced Functional Materials, 32 (38). 2205802. ISSN 1616-301X (https://doi.org/10.1002/adfm.202205802)

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Abstract

Materials that combine the functionalities of both of proteins and graphene are of great interest for the engineering of biosensing, drug delivery, and regenerative devices. Graphene oxide (GO) offers an opportunity to design GO‐protein interactions but the need for harsh reduction processes to enable GO photoexcitation remains a limitation. A disinfector‐assisted low temperature method to reduce GO‐protein materials and fabricate surgical dressings with tuneable photothermal efficiency and bioactive properties for the postoperative treatment of melanoma is reported. The approach harnesses the capacity of 70% ethanol to penetrate the protein shell of microorganisms to infiltrate GO‐protein complexes and reduce GO at low temperature (85 °C) while maintaining the material structure and bioactivity. Both experiments and coarse‐grained simulations are used to describe the reduction process and assess the material properties. In vitro and in vivo validation revealed the capacity of the dressings to prevent tumor recurrence and promote healing after tumor resection.

ORCID iDs

Wu, Yuanhao, Yang, Junyao, van Teijlingen, Alexander ORCID logoORCID: https://orcid.org/0000-0002-3739-8943, Berardo, Alice, Corridori, Ilaria, Feng, Jingyu, Xu, Jing, Titirici, Maria‐Magdalena, Rodriguez‐Cabello, Jose Carlos, Pugno, Nicola M, Sun, Jiaming, Wang, Wen, Tuttle, Tell and Mata, Alvaro;
  • Item type:Article
    ID code:81506
    Dates:
    Date
    Event
    19 September 2022
    Published
    8 July 2022
    Published Online
    7 June 2022
    Accepted
    21 May 2022
    Submitted
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:21 Jul 2022 09:29
    Last modified:18 Nov 2024 15:04
    URI:https://strathprints.strath.ac.uk/id/eprint/81506
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