Synthesis of ( + ) - ( R )-tiruchanduramine

Al-Taie, Zahraa S. and Bartholomew, Barbara and Cartmell, Christopher and Froom, Richard T. and Kerr, Russell G. and Kraehenbuehl, Rolf and Murphy, Patrick J. and Nash, Robert J. and Penkova, Yana B. and van Teijlingen, Alexander (2022) Synthesis of ( + ) - ( R )-tiruchanduramine. Molecules, 27 (4). 1338. ISSN 1420-3049 (

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The absolute stereochemistry of the marine alkaloid (+)-(R)-tiruchanduramine was established via a convergent total synthesis in six steps and 15.5% overall yield from Fmoc-D-Dab(Boc)-OH.