Characterization of polymeric nanoparticle-protein interactions

Daramy, Karim and Minelli, Caterina and Perrie, Yvonne and Rattray, Zahra (2021) Characterization of polymeric nanoparticle-protein interactions. In: American Association of Pharmaceutical Scientists 2021, 2021-10-17 - 2021-10-20, Boston Convention & Exhibition Center.

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Abstract

Polymeric nanoparticles have shown significant potential for the development of new medicines for unmet clinical need. Upon administration into protein-containing media, proteins will spontaneously adsorb onto the surface of nanoparticles and form a 'protein corona'. Protein corona formation alters the physiochemical properties of nanoparticles which consequently impacts their biological fate. The aim of this study was to develop a robust pipeline for the reproducible characterization of polymeric nanoparticles following protein corona formation.

ORCID iDs

Daramy, Karim, Minelli, Caterina, Perrie, Yvonne and Rattray, Zahra ORCID logoORCID: https://orcid.org/0000-0002-8371-8549;
CORE (COnnecting REpositories)