Three-dimensional bioprinting of stem-cell derived tissues for human regenerative medicine

Skeldon, Gregor and Lucendo-Villarin, Baltasar and Shu, Wenmiao (2018) Three-dimensional bioprinting of stem-cell derived tissues for human regenerative medicine. Philosophical Transactions B: Biological Sciences, 373. 20170224. ISSN 0962-8436 (https://doi.org/10.1098/rstb.2017.0224)

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Abstract

Stem cell technology in regenerative medicine has the potential to provide an unlimited supply of cells for drug testing, medical transplantation and aca-demic research. In order to engineer a realistic tissue model using stem cells as an alternative to human tissue, it is essential to create artificial stem cell microenvironment or niches. Three-dimensional (3D) bioprinting is a promising tissue engineering field that offers new opportunities to precisely place stem cells within their niches layer-by-layer. This review covers bioprinting technologies, the current development of 'bio-inks' and how bioprinting has already been applied to stem-cell culture, as well as their applications for human regenerative medicine. The key considerations for bioink properties such as stiffness, stability and biodegradation, biocompatibility and print- ability are highlighted. Bioprinting of both adult and pluriopotent stem cells for various types of artificial tissues from liver to brain has been reviewed. 3D bioprinting of stem-cell derived tissues for human regenerative medicine is an exciting emerging area that represents opportunities for new research, industries and products as well as future challenges in clinical translation.

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