Biofabrication for soft tissue and cartilage engineering
Turnbull, Gareth and Clarke, Jon and Picard, Frédéric and Zhang, Weidong and Riches, Philip and Li, Bin and Shu, Wenmiao (2020) Biofabrication for soft tissue and cartilage engineering. Medical Engineering and Physics, 82. pp. 13-39. ISSN 1873-4030 (https://doi.org/10.1016/j.medengphy.2020.06.003)
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Abstract
Soft tissue injuries (STIs) affect patients of all age groups and represent a common worldwide clinical problem, resulting from conditions including trauma, infection, cancer and burns. Within the spectrum of STIs a mixture of tissues can be injured, ranging from skin to underlying nerves, blood vessels, tendons and cartilaginous tissues. However, significant limitations affect current treatment options and clinical demand for soft tissue and cartilage regenerative therapies continues to rise. Improving the regeneration of soft tissues has therefore become a key area of focus within tissue engineering. As an emerging technology, 3D bioprinting can be used to build complex soft tissue constructs "from the bottom up," by depositing cells, growth factors, extracellular matrices and other biomaterials in a layer-by-layer fashion. In this way, regeneration of cartilage, skin, vasculature, nerves, tendons and other bodily tissues can be performed in a patient specific manner. This review will focus on recent use of 3D bioprinting and other biofabrication strategies in soft tissue repair and regeneration. Biofabrication of a variety of soft tissue types will be reviewed following an overview of available cell sources, bioinks and bioprinting techniques.
ORCID iDs
Turnbull, Gareth, Clarke, Jon, Picard, Frédéric, Zhang, Weidong, Riches, Philip ORCID: https://orcid.org/0000-0002-7708-4607, Li, Bin and Shu, Wenmiao ORCID: https://orcid.org/0000-0002-1220-361X;-
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Item type: Article ID code: 78634 Dates: DateEvent31 August 2020Published9 July 2020Published Online8 June 2020AcceptedSubjects: Technology > Engineering (General). Civil engineering (General) > Bioengineering Department: Faculty of Engineering > Biomedical Engineering Depositing user: Pure Administrator Date deposited: 18 Nov 2021 12:18 Last modified: 02 Oct 2024 10:45 URI: https://strathprints.strath.ac.uk/id/eprint/78634