Investigation into the use of microfluidics in the manufacture of metallic gold-coated iron oxide hybrid nanoparticles
Oluwasanmi, Adeolu and Man, Ernest and Curtis, Anthony and Yiu, Humphrey H. P. and Perrie, Yvonne and Hoskins, Clare (2021) Investigation into the use of microfluidics in the manufacture of metallic gold-coated iron oxide hybrid nanoparticles. Nanomaterials, 11 (11). 2976. ISSN 2079-4991 (https://doi.org/10.3390/nano11112976)
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Abstract
Hybrid iron oxide-gold nanoparticles are of increasing interest for applications in nanomedicine, photonics, energy storage, etc. However, they are often difficult to synthesise without experience or ‘know-how’. Additionally, standard protocols do not allow for scale up, and this is significantly hindering their future potential. In this study, we seek to determine whether microfluidics could be used as a new manufacturing process to reliably produce hybrid nanoparticles with the line of sight to their continuous manufacture and scaleup. Using a Precision Nano NanoAssemblr Benchtop® system, we were able to perform the intermediate coating steps required in order to construct hybrid nanoparticles around 60 nm in size with similar chemical and physical properties to those synthesised in the laboratory using standard processes, with Fe/Au ratios of 1:0.6 (standard) and 1:0.7 (microfluidics), indicating that the process was suitable for their manufacture with optimisation required in order to configure a continuous manufacturing plant.
ORCID iDs
Oluwasanmi, Adeolu, Man, Ernest, Curtis, Anthony, Yiu, Humphrey H. P., Perrie, Yvonne and Hoskins, Clare ORCID: https://orcid.org/0000-0002-7200-0566;-
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Item type: Article ID code: 78454 Dates: DateEvent5 November 2021Published5 November 2021Published Online3 November 2021AcceptedSubjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical SciencesDepositing user: Pure Administrator Date deposited: 08 Nov 2021 14:08 Last modified: 30 Nov 2024 14:18 URI: https://strathprints.strath.ac.uk/id/eprint/78454