Multiple myeloma : therapeutic delivery of antibodies and aptamers

Pujol-Navarro, Neret and Al Qaraghuli, Mohammed M and Kubiak-Ossowska, Karina and Alsaadi, Manal M and Horne, Gillian A and Soutar, Richard L and Paspali, Elpiniki and Ferro, Valerie A and Williams, Mark TS and Mulheran, Paul A (2021) Multiple myeloma : therapeutic delivery of antibodies and aptamers. Therapeutic Delivery, 12 (10). pp. 705-722. ISSN 2041-5990 (

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Multiple myeloma is the second most common hematological malignancy in adults, accounting for 2% of all cancer-related deaths in the UK. Current chemotherapy-based regimes are insufficient, as most patients relapse and develop therapy resistance. This review focuses on current novel antibody- and aptamer-based therapies aiming to overcome current therapy limitations, as well as their respective limitations and areas of improvement. The use of computer modeling methods, as a tool to study and improve ligand-receptor alignments for the use of novel therapy development will also be discussed, as it has become a rapid, reliable and comparatively inexpensive method of investigation.