Sono-magnetic heating in tumor phantom

Kaczmarek, Katarzyna and Hornowski, Tomasz and Antal, Iryna and Rajnak, Michal and Timko, Milan and Józefczak, Arkadiusz (2020) Sono-magnetic heating in tumor phantom. Journal of Magnetism and Magnetic Materials, 500. 166396. ISSN 0304-8853 (

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There exist various types of hyperthermia therapy such as radiofrequency, infrared, microwave, focused ultrasound or magnetic. Recently, a lot of effort has been put into combining more than one mode of heating into one treatment. The multimodal hyperthermia proves a better alternative in comparison with a single one. In this paper, we show that the application of dual sono-magnetic heating (ultrasound and magnetic together) gives better results than using either of them alone. The advantage of this bimodal treatment lies not only in cumulative heating of target volume (tumor) but also in synergistic interaction between the two mechanisms—the ultrasound sonication can improve the thermal effect of magnetic hyperthermia through the unblocking Brown’s relaxation. Furthermore, the ultrasound and magnetic heating are complementary to each other. The temperature rise caused by ultrasound is fast changing and by magnetic field slow changing. So the parameters of ultrasound can serve as coarse-tuning settings of heating while the parameters of the magnetic field as fine-tuning enabling more precise hyperthermia.